Investigating the Evolution of Innate and Adaptive Cellular Immunity

Grant number: DP190103282 | Funding period: 2019 - 2022

Completed

Abstract

This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an initial screen, distinct variants and combinations of these genes were identified. This project aims to interrogate how variation in these critical genes impacts on the function of cytotoxic lymphocytes, providing insights into the evolutionary drivers of immune recognit..

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Related publications (2)

An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania

Liyen Loh, Philippa M Saunders, Camilla Faoro, Neus Font-Porterias, Neda Nemat-Gorgani, Genelle F Harrison, Suraju Sadeeq, Luca Hensen, Shu Cheng Wong, Jacqueline Widjaja, E Bridie Clemens, Shiying Zhu, Katherine M Kichula, Sudan Tao, Faming Zhu, Gonzalo Montero-Martin, Marcelo Fernandez-Vina, Lisbeth A Guethlein, Julian P Vivian, Jane Davies

2024-11-27

Genetic variation in host immunity impacts the disproportionate burden of infectious diseases that can be experienced by First Nat..

CD8 T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

L Hensen, PT Illing, E Bridie Clemens, THO Nguyen, M Koutsakos, CE van de Sandt, NA Mifsud, AT Nguyen, C Szeto, BY Chua, H Halim, S Rizzetto, F Luciani, L Loh, EJ Grant, PM Saunders, AG Brooks, S Rockman, TC Kotsimbos, AC Cheng

2021-12-01

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

University of Melbourne Researchers

Katherine Kedzierska

Andrew Brooks